艾滋病的终结:艾滋病毒感染作为一种慢性疾病
Steven G Deeks1, Sharon R Lewin, Diane V Havlir
1Department of Medicine, University of California, San Francisco, CA, USA.
Lancet (London, England)
|October 25, 2013
概括
抗逆转录病毒疗法将艾滋病转化为慢性艾滋病毒疾病. 长期治疗会导致新的并发症,增加对治愈艾滋病毒的需求.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 抗逆转录病毒疗法 (ART) 显著改善了艾滋病毒/艾滋病患者的治疗结果.
- 艺术已经从一种绝症转变为一种慢性,终身的疾病.
- 尽管ART成功,但艾滋病毒仍然是一个复杂的慢性疾病,并会出现并发症.
研究的目的:
- 通过有效的ART检查与艾滋病毒感染者的长期健康后果.
- 突出艾滋病毒作为一种慢性疾病的管理中不断变化的挑战.
- 强调解决艾滋病毒相关并发症和寻找治愈的日益重要.
主要方法:
- 这项研究是对当前关于艾滋病毒管理和长期结果的文献进行叙事审查.
- 分析有关艾滋病毒相关并发症的数据,包括心血管疾病,癌症和代谢障碍.
- 几十年来累积抗逆转录病毒药物毒性的影响的检查.
主要成果:
- 艾滋病毒现在是患者获得终身ART的慢性疾病,与艾滋病相关的疾病不再是主要威胁.
- 心血管疾病和癌症等新的并发症正在增加,原因是免疫恢复不完整和炎症.
- 长期使用ART会导致累积的毒性作用,导致代谢障碍和末端器官损伤.
结论:
- 艾滋病毒管理已经演变为终身慢性疾病,需要持续的护理.
- 与艾滋病毒相关的并发症负担日益增加,对健康老龄化和医疗保健系统构成挑战,特别是在资源有限的环境中.
- 鉴于长期管理的复杂性和潜在的压倒性医疗保健系统,全球努力寻找治愈艾滋病毒至关重要.
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