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In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
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过度表达SHANK3会导致具有独特的药物遗传特性的躁狂行为

Kihoon Han1, J Lloyd Holder, Christian P Schaaf

  • 11] Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA [2] Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA [3] Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030, USA.

Nature
|October 25, 2013
PubMed
概括

过度表达SHANK3基因会导致高动力神经精神疾病,包括躁狂类行为和发作. 酸治疗可能有助于管理这些情况,与不同.

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