多种药物两性:用于形状调节的细胞内化,贩运和药物输送的等级组件
Xianglong Hu1, Jinming Hu, Jie Tian
1CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China , Hefei, Anhui 230026, China.
Journal of the American Chemical Society
|October 29, 2013
概括
研究人员开发了新型的多种药物双活体,可以自组装成独特的纳米结构. 在药物输送应用中,分层片表现出卓越的性能,包括扩展血液循环和更快的细胞吸收.
科学领域:
- 聚合物化学 聚合物化学
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 块共聚物 (BCP) 自组装通常会产生球体,棒和囊泡.
- 稳定的平面纳米结构由于双层曲,很难制造.
- 了解纳米载体细胞相互作用的形状影响和优化药物递送性能是具有挑战性的.
研究的目的:
- 合成和表征新型的多种药物双活体,以便自组装成各种纳米结构.
- 为了研究高坎普托西因 (CPT) 负载的PEG-b-PCPTM多种药物两的自我组装行为.
- 为了评估不同纳米结构的性能,特别是分阶层的叶片,在药物输送应用中.
主要方法:
- 合成聚乙烯甘醇) 块聚合的坎普托丁 (PEG-b-PCPTM) 多种药物两性药物的合成.
- 通过溶液自组装形成的纳米结构的表征,包括球体,囊泡,磁盘和分阶层的片.
- 在实验室中评估纳米结构的性能,包括血液循环持续时间,细胞吸收,药物释放动力学,降解和细胞毒性.
主要成果:
- PEG-b-PCPTM的多种药物双活体自我组装成四个不同的纳米结构,重量>50%的CPT负荷.
- 观察到前所未有的带有尖尖的外围的分层斑块.
- 与其他形态学相比,分层的片表现出卓越的性能,包括扩展血液循环,快速的细胞吸收和独特的内化通路.
结论:
- 控制的多种药物两性动物的等级组织使多种纳米结构的形成成为可能.
- 可调整形状的生物性能,特别是带有分阶层的叶片,为下一代基于BCP的药物递送系统提供了巨大的潜力.
- 这项工作为设计具有增强治疗效率的先进纳米载体开辟了新的途径.
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