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在物种内部,遗传不相容性很普遍

Russell B Corbett-Detig¹, Jun Zhou, Andrew G Clark

¹Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

|November 8, 2013

概括

表观性,或非添加性等位基因相互作用,显著影响健身. 研究人员通过检测基因型比率扭曲发现了Drosophila melanogaster的广泛表观症,这表明它在进化和物种化中发挥着关键作用.

科学领域:

进化遗传学的进化遗传学
人口遗传学人口遗传学
基因组学就是基因组学.

背景情况:

表观性 (非添加性等位基相互作用) 对于人口健康至关重要,但在经验上具有挑战性.
传统方法从特征特定的基因型值非独立性推断出表观性.
健身的表现应该留下一个可检测的基因组足迹.

研究的目的:

开发和应用一种基于基因型比率扭曲的新方法来检测表皮病.
经验证实基因型比率扭曲作为表皮性健康效应的签名.
评估Drosophila melanogaster种群中表皮病的流行率.

主要方法:

开发了一种检测基因型比率扭曲的方法,作为表观病的指标.
将这种方法应用于Drosophila melanogaster重组杂交系的大型小组.
实验证实了基因型比率扭曲与表皮性健康效应之间的联系.

主要成果:

证实基因型比率扭曲意味着具有表皮性健康效应的位置.
据估计,研究中的任何两个单 haploid 基因组均含有平均 1.15 对表观交互的等位基因.
证明了表皮病是普遍存在的,并且经常可能未被发现.

结论:

表观症是一种常见的塑造健康的力量,通过基因型比率扭曲可以轻松检测到.
病的流行为生殖隔离提供了原材料,影响了物种化遗传学.
这些发现挑战了用于生殖隔离的全方位突变分歧的必要性,突出了当代物种内部的遗传变异.

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