Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Tissue Injury: Inflammation and Repair01:28

Tissue Injury: Inflammation and Repair

4.9K
4.9K
Healing I: Introduction01:11

Healing I: Introduction

15
Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...
15
Inflammatory Response01:28

Inflammatory Response

12.5K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
12.5K
Liver Regeneration01:24

Liver Regeneration

4.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.2K
Phases of Wound Repair01:28

Phases of Wound Repair

8.0K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
8.0K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

8.4K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
8.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Single-cell transcriptomics and RNAi screening define a hierarchical program of planarian eye regeneration.

Cell reports·2026
Same author

<i>map3k1</i> is required for spatial restriction of progenitor differentiation in planarians.

eLife·2026
Same author

The planarian dorsal-ventral boundary regulates anterior-posterior axis growth and patterning.

PLoS biology·2025
Same author

egal-1 and microtubules promote regeneration polarity in planarians.

Development (Cambridge, England)·2025
Same author

<i>map3k1</i> is required for spatial restriction of progenitor differentiation in planarians.

bioRxiv : the preprint server for biology·2025
Same author

Coordinated neuron-glia regeneration through Notch signaling in planarians.

PLoS genetics·2025

相关实验视频

Updated: May 6, 2026

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

12.9K

林28:时间用于组织修复.

Peter W Reddien1

  • 1Howard Hughes Medical Institute, MIT Biology, and Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142, USA.

Cell
|November 12, 2013
PubMed
概括

胚胎基因Lin28a在出生后被激活时,可显著增强小鼠的组织修复. 这一发现为再生医学提供了新的见解,并改善了成年哺乳动物的愈合过程.

科学领域:

  • 发育生物学是发展生物学.
  • 再生医学是一种再生医学.
  • 分子生物学分子生物学

背景情况:

  • 与成年人相比,胚胎和青少年有机体表现出优越的组织修复能力.
  • 治愈能力的这种差异与发育过程和基因表达模式有关.

研究的目的:

  • 为了研究Lin28a的作用,一个在胚胎发育过程中正常活跃的基因,在成人的组织修复中.
  • 为了确定重新激活胚胎基因通路是否可以增强产后的再生过程.

主要方法:

  • 成年小鼠中Lin28a基因的产后激活.
  • 诱导组织损伤,特别是耳朵和手指.
  • 评估Lin28a激活后的修复效率和组织再生.

主要成果:

  • 产后激活Lin28a促进了超出正常成年人的能力的组织修复.
  • 在耳朵和手指受伤的愈合过程中观察到显著的改善.
  • 在成年组织中,Lin28a似乎调解了增强的再生潜力.

结论:

  • 林28a重新激活是一种可行的策略,可以促进成年哺乳动物的组织修复.

更多相关视频

Using R, Seurat, and CellChat to Analyze a Single-Cell Transcriptomics Dataset of Mouse Skin Wound Healing
08:58

Using R, Seurat, and CellChat to Analyze a Single-Cell Transcriptomics Dataset of Mouse Skin Wound Healing

Published on: August 1, 2025

3.9K
Capturing Tissue Repair in Zebrafish Larvae with Time-lapse Brightfield Stereomicroscopy
14:29

Capturing Tissue Repair in Zebrafish Larvae with Time-lapse Brightfield Stereomicroscopy

Published on: January 31, 2015

12.3K

相关实验视频

Last Updated: May 6, 2026

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

12.9K
Using R, Seurat, and CellChat to Analyze a Single-Cell Transcriptomics Dataset of Mouse Skin Wound Healing
08:58

Using R, Seurat, and CellChat to Analyze a Single-Cell Transcriptomics Dataset of Mouse Skin Wound Healing

Published on: August 1, 2025

3.9K
Capturing Tissue Repair in Zebrafish Larvae with Time-lapse Brightfield Stereomicroscopy
14:29

Capturing Tissue Repair in Zebrafish Larvae with Time-lapse Brightfield Stereomicroscopy

Published on: January 31, 2015

12.3K
  • 这一发现为再生医学中的治疗干预开辟了新的途径.
  • 了解Lin28a的分子机制可能会导致创伤恢复的新疗法.