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Updated: May 5, 2026

A High-throughput-compatible FRET-based Platform for Identification and Characterization of Botulinum Neurotoxin Light Chain Modulators
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通过肉神经毒素A识别突触囊泡蛋白2C的结构基础

Roger M Benoit1, Daniel Frey2, Manuel Hilbert2

  • 1Laboratory of Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland.

Nature
|November 19, 2013
PubMed
概括

肉毒神经毒素A (BoNT/A) 通过其受体结合域与SV2C结合. 这种对BoNT/A-SV2C相互作用的结构洞察力有助于开发新的抗毒素和治疗毒素变体.

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