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Updated: May 5, 2026

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
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Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells

Published on: July 29, 2015

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纤维细胞直接重新编程到神经元的等级机制

Orly L Wapinski1, Thomas Vierbuchen, Kun Qu

  • 1Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University, Stanford, CA 94305, USA; Program in Cancer Biology, Stanford University, Stanford, CA 94305, USA.

Cell
|November 19, 2013
PubMed
概括

直接血统重编程使用转录因子来转换细胞. Ascl1开创了基因访问,招募了像Brn2这样的基因,使诱导的神经元 (iN) 细胞生成成为可能.

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Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts09:07

Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts

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Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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