全球动脉瘤流行病学研究:公共卫生措施可以进一步降低腹腔大动脉瘤死亡率
David Sidloff1, Philip Stather, Nikesh Dattani
1Vascular Surgery Group, Department of Cardiovascular Sciences (D.S., P.S., N.D., M.B., R.S., E.C.) and Department of Health Sciences (J.T.), University of Leicester, Leicester, UK.
Circulation
|November 20, 2013
概括
全球腹腔大动脉瘤 (AAA) 死亡率并没有普遍下降,但各国之间存在显著差异. 吸烟率的下降显示了与AAA死亡率的减少最强的相关性,而肥胖症则是一个悖论.
科学领域:
- 心血管流行病学心血管流行病学
- 公共卫生 公共卫生
背景情况:
- 西方数据显示,腹腔大动脉动脉瘤 (AAA) 死亡率正在下降,但全球趋势尚不清楚.
- 调查国际AAA死亡率及其与心血管风险因素的联系至关重要.
研究的目的:
- 检查从1994年至2010年腹腔大动脉瘤 (AAA) 死亡率的全球趋势.
- 分析AAA死亡率和心血管风险因素之间的关联.
主要方法:
- 利用了世界卫生组织的死亡率数据和来自19个世卫组织成员国的风险因素统计数据.
- 进行回归分析,以将心血管风险因素的时间趋势与AAA死亡率相关联.
主要成果:
- 在全球范围内,AAA死亡率趋势呈现出显著的异质性;美国和英国的死亡率下降幅度最大.
- 在几个欧洲国家,AAA死亡率有所增加,这表明非普遍的下降.
- 在AAA死亡率与静脉压,胆固醇和吸烟率之间发现了积极的关联. 观察到与体重指数的反向关联.
结论:
- 全球AAA死亡率并未均下降,国家差异与心血管风险因素有关.
- 吸烟率的下降与AAA死亡率的降低密切相关.
- 在AAA死亡率中的"肥胖悖论"需要对公共卫生策略进行进一步调查.
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