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K-Ras (G12C) 抑制剂可以全质地控制GTP亲和力和效应因子相互作用.

Jonathan M Ostrem1, Ulf Peters, Martin L Sos

  • 11] Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, California 94158, USA [2].

Nature
|November 22, 2013
PubMed
概括

研究人员开发了针对K-Ras (G12C) 癌症突变的新型小分子. 这些抑制剂结合不可逆转,创建一个新的可向部位,并提供突变特异性治疗策略.

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