嗅觉控制血前代的维持 血前代的维持
Jiwon Shim1, Tina Mukherjee, Bama Charan Mondal
1Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Cell
|November 26, 2013
概括
嗅觉受体神经元 (ORNs) 通过GABA向Drosophila的血前代发出信号,维持血液造血干细胞. 缺少气味刺激会损害血液原始体的维持,将感官知觉与免疫联系起来.
科学领域:
- 发育生物学 发展生物学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 在Drosophila中,造血原体的维持依赖于局部和全身的线索.
- 感官感知在调节先天免疫力和血细胞发育中的作用尚未完全理解.
研究的目的:
- 为了研究感官知觉,特别是嗅觉,与Drosophila的造血原体维持之间的联系.
- 阐明嗅觉刺激影响血细胞发育的分子和细胞机制.
主要方法:
- 使用Drosophila melanogaster作为一个模型生物.
- 采用基因操纵来识别和表征涉及的细胞类型 (嗅觉受体神经元,神经分泌细胞).
- 研究的信号通路包括GABAergic信号传递和血液祖先中的 (Ca2+) 动态.
主要成果:
- 发现嗅觉受体神经元 (ORN) 调节产生GABA的神经分泌细胞.
- 嗅觉刺激导致GABA分泌到血淋巴,激活淋巴腺前体上的GABAB受体.
- GABA信号诱导高细胞溶液Ca2+,这对于维持造血原始体至关重要且足够.
- 在低气味环境中养的幼虫显示无法维持造血原始体.
结论:
- 感官感知,特别是嗅觉刺激,对于维持Drosophila的血液生成原始体至关重要.
- 通过GABAergic信号传递确定了一条新的途径,将嗅觉感知与血液前体维持联系起来.
- 通过气味剥夺破坏这种感觉免疫联系,危害了造血干细胞池和天生的免疫力.
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