远程缺血预约对血小板激活和通过动诱导的血小板活性对心房动的影响
Alessandra Stazi1, Giancarla Scalone, Marianna Laurito
1Institute of Cardiology, Università Cattolica del Sacro Cuore, Rome, Italy.
Circulation
|November 27, 2013
概括
在心房移除前的远程缺血预条件 (IPC) 减少了程序诱导的血小板激活. 这一发现表明,IPC可以减轻与射频废除相关的血栓栓塞风险.
科学领域:
- 心脏病学 心脏病学
- 血管生物学 血管生物学
- 干预性电生理学 干预性电生理学
背景情况:
- 对于心房动的射频移除,存在血栓栓塞事件的风险.
- 远程缺血预调 (IPC) 之前已经证明可以降低运动诱导的血小板反应性.
- 这项研究研究了IPC在心房动中对血小板激活的影响.
研究的目的:
- 为了确定远程IPC是否可以降低心房动患者的射频剥离引起的血小板激活.
- 评估IPC对血小板激活和反应性的特定标记物的影响.
主要方法:
- 这是一项随机对照试验,涉及19名接受放射频导管切除治疗的患者,因为他们患有阳性心房动.
- 患者被分配到远程IPC或在切除前的假手术中.
- 使用流细胞计测量测量了血小板激活,分析了不同时间点的单细胞-血小板聚合物和血小板表面标记物 (CD41,CD62).
主要成果:
- 射频剥离在IPC和对照组中增加了血小板激活,持续24小时.
- 与对照组相比,接受远程IPC的患者表现出单细胞 - 血小板聚合形成和血小板CD41和CD62表达的显着较低.
- 远程IPC还显著降低了所有测量的血小板标记物的ADP诱导的增加.
结论:
- 远程IPC显著减轻了随着放射频导管切除用于心房动症的血小板激活和反应率的增加.
- 这些发现表明远程IPC在减少血栓栓塞并发症方面具有潜在的保护作用.
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