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瘤性Nras对干细胞具有双式效应,可可持续地提高竞争力

Qing Li1, Natacha Bohin1, Tiffany Wen1

  • 1Department of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.

Nature
|November 29, 2013
PubMed
概括

激活NRAS突变促进了造血干细胞 (HSC) 的增殖和自我更新. 这通过一种双模机制发生,在这种机制中,罕见地分裂的突变HSC超越了正常的HSC,推动了白血病前扩张.

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