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相关概念视频

Hepatitis01:25

Hepatitis

99
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
99
Viral Structure00:56

Viral Structure

59.2K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
59.2K
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

28
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
28
Antibody Structure01:10

Antibody Structure

52.5K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
52.5K
Antibody Structure01:10

Antibody Structure

12.0K
12.0K
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

1.2K
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
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相关实验视频

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A Protocol for Analyzing Hepatitis C Virus Replication
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肝炎C病毒E2包裹糖蛋白核心结构

Leopold Kong1, Erick Giang, Travis Nieusma

  • 1Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|November 30, 2013
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概括
此摘要是机器生成的。

分析了型肝炎病毒E2信封糖蛋白的结构,揭示了一个紧的形式,与预测的模型不同. 这一发现为开发新的C型肝炎病毒 (HCV) 药物和疫苗提供了关键的见解.

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科学领域:

  • 病毒学 病毒学
  • 结构生物学 结构生物学
  • 免疫学 免疫学 免疫学

背景情况:

  • 肝炎C病毒 (HCV) 导致严重的肝病,包括肝硬化和癌症.
  • 肝炎病毒包膜糖蛋白E1和E2对于病毒进入至关重要,是免疫反应的关键标.

研究的目的:

  • 为了确定HCV E2核心蛋白的结构基础.
  • 为了确定CD81受体的结合部位及其与抗体表位的关系.

主要方法:

  • 使用X射线晶体学来确定与抗体AR3C结合的E2核心的结构.
  • 电子显微镜和局部定向突变发生被用来绘制CD81结合部位的地图.

主要成果:

  • 晶体结构显示了一个紧的E2核心架构,与以前的预测不同.
  • 确定了CD81受体的结合部位,并发现与广泛中和抗体AR3C表位相重叠.

结论:

  • 确定的E2结构为HCV进入机制提供了新的理解.
  • 这些结构性见解对于设计有效的HCV治疗方法和疫苗非常有价值.