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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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列纳利多米德会在多发性骨髓瘤细胞中导致IKZF1和IKZF3的选择性降解

Jan Krönke1, Namrata D Udeshi, Anupama Narla

  • 1Brigham and Women's Hospital, Boston, MA 02115, USA.

Science (New York, N.Y.)
|December 3, 2013
PubMed
概括

列纳利多米德通过改变E3无素酶活性来选择性降解淋巴细胞转录因子IKZF1和IKZF3. 这种机制解释了其在多发性骨髓瘤和其他B细胞癌症中的有效性.

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