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HMGA2作为一种竞争的内源RNA,促进肺癌的进展

Madhu S Kumar1, Elena Armenteros-Monterroso1, Philip East2

  • 1Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.

Nature
|December 6, 2013
PubMed
概括

高流动性组AT-hook 2 (Hmga2) 通过作为Let-7微RNA (miRNA) 的竞争性内源性RNA (ceRNA) 来驱动肺癌的进展和转移. 这种作为蛋白质和ceRNA的双重功能,突出了非小细胞肺癌中一种新的致癌机制.

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