压缩用于预防血栓后综合征:一个随机的安慰剂对照试验
Susan R Kahn1, Stan Shapiro2, Philip S Wells3
1Centre for Clinical Epidemiology, Jewish General Hospital, Montreal, QC, Canada.
Lancet (London, England)
|December 10, 2013
概括
弹性压缩 (ECS) 没有防止深静脉血栓症 (DVT) 后的血栓后综合征 (PTS). 这项研究发现,使用活性ECS和安慰剂的患者之间的PTS发病率没有显著差异.
科学领域:
- 血管医学 血管医学
- 临床试验 临床试验
- 医疗器械 医疗器械
背景情况:
- 血栓后综合征 (PTS) 是深静脉血栓症 (DVT) 后的一个常见并发症.
- 关于用于预防PTS的弹性压缩 (ECS) 的先前研究受到小样本大小和缺乏安慰剂对照的限制.
- 对于ECS在DVT后预防PTS的有效性仍然不确定.
研究的目的:
- 评估弹性压缩 (ECS) 与安慰剂相比,在第一个近道深静脉血栓塞 (DVT) 发生后预防血栓后综合征 (PTS) 的有效性.
主要方法:
- 一个多中心,随机,安慰剂对照试验,涉及第一次近端DVT的患者.
- 参与者被分配到活跃的ECS或安慰剂子中,持续2年.
- 主要结局是使用金斯伯格的标准在6个月或更晚的时候诊断出PTS.
主要成果:
- 在活跃的ECS组中,PTS的累积发病率为14.2%,在安慰剂组中为12.7% (HR 1.13,95% CI 0.73-1.76;p=0.58).
- 在活性ECS和安慰剂组之间没有观察到PTS发展的显著差异.
- 对频繁养用户的每条协议分析也产生了类似的结果.
结论:
- 弹性压缩 (ECS) 在第一个近道深静脉血栓瘤 (DVT) 之后,没有显示出对血栓后综合征 (PTS) 的预防作用.
- 这些发现不支持常规使用ECS来预防DVT后的PTS.
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