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Updated: May 4, 2026

Generation of Integration-free Induced Pluripotent Stem Cells from Human Peripheral Blood Mononuclear Cells Using Episomal Vectors
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C/EBPα使B细胞迅速重新编程成诱导的多能干细胞

Bruno Di Stefano1, Jose Luis Sardina2, Chris van Oevelen2

  • 11] Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), Dr Aiguader 88, 08003 Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Dr Aiguader 88, 08003 Barcelona, Spain.

Nature
|December 17, 2013
PubMed
概括

CCAAT/增强剂结合蛋白-α (C/EBPα) 通过增加色素可访问性来增强诱导的多能干细胞 (iPS) 重编程. 它还调节Tet2,这是一种对去甲基化多能基因至关重要的二氧化酶,并将iPS细胞生成与B细胞转基因差异化联系起来.

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