通过1,1-碳化形成醇
Fang Ge1, Gerald Kehr, Constantin G Daniliuc
1Organisch-Chemisches Institut, Universität Münster , Corrensstrasse 40, D-48149 Münster, Germany.
Journal of the American Chemical Society
|December 21, 2013
概括
研究人员从乙烯基和易斯酸中合成了新型醇. 这些醇可以稳定或经历循环添加反应,扩大了有机化学中的合成可能性.
科学领域:
- 有机金属化学 有机金属化学
- 化学 化学
- 合成有机化学 合成有机化学
背景情况:
- 醇是含的异环化合物,在材料科学和催化中具有应用.
- 新型醇衍生物的合成仍然是一个活跃的研究领域,寻求新的结构和反应性.
- 路易斯酸介导的反应提供了构建复杂含异环的途径.
研究的目的:
- 为了合成和表征由乙烯基烯酸衍生出的新醇化合物.
- 研究这些新型醇的反应性,包括稳定和循环添加反应.
- 探索三 (pentafluorophenyl) 作为易斯酸在醇合成中的实用性.
主要方法:
- 在环境温度下,二三甲基乙烯二胺与三五二 (BC6F5) 3 的反应.
- 通过与二酸形成添加物稳定所产生的.
- 双二甲三甲乙烯烯与BC6F5的反应3随后处理3-hexyne.
主要成果:
- 反应产生了醇 (9) 和一个微小的热后续产物 (12).
- 醇9被成功稳定为二胺添加物 (10).
- 一个单独的反应产生醇14,它经历了 [4 + 2] 循环添加与3-基因以获得产品15.
结论:
- 新型醇结构是使用易斯酸介导方法合成的.
- 合成的醇表现出可调节的反应性,允许稳定或参与循环添加反应.
- 这项研究扩展了合成工具箱,以访问功能化的有机异环.
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