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作为高度敏感的化学物质交换和转移MRI对比剂的兰化物载体红细胞

Giuseppe Ferrauto¹, Daniela Delli Castelli, Enza Di Gregorio

¹Department of Molecular Biotechnology and Health Sciences, Molecular Imaging and Preclinical Centers, University of Torino , Torino, Italy.

Journal of the American Chemical Society

|December 24, 2013

概括

研究人员开发了一种高度敏感的化学交换和转移 (CEST) 剂,使用载有偏磁转移试剂的红细胞 (RBC). 这种新的方法可以提高MRI对比度,用于分子成像和瘤血液体积评估.

科学领域:

磁共振成像 (MRI) 是一种磁共振成像技术.
生物医学工程生物医学工程
纳米技术纳米技术

背景情况:

化学交换和转移 (CEST) 剂是先进的MRI对比剂,具有分子和细胞成像的潜力.
目前的CEST代理的主要局限性是它们的低灵敏度,阻碍了详细分析.
提高灵敏度需要增加对和磁化转移到水信号的质子交换.

研究的目的:

开发一种新型,高度敏感的CEST剂,用于增强核磁共振.
研究使用红细胞作为CEST成像平台.
探索该系统在体内应用的潜力,包括瘤血液体积评估.

主要方法:

在红细胞内捕获寄磁转移试剂的细胞内捕获,以转移水质子化学转移.
利用红细胞中的细胞质水分子作为可交换质子的来源.
评估开发的MRI系统的灵敏度和适用性.

主要成果:

证明RBC中的细胞内转移水可以作为CEST可交换质子的高效来源.
通过新系统实现了前所未有的灵敏度,检测到低至1 pM的细胞度.
该系统的天然起源使其适用于体内应用.

结论:

开发了一种新且高度敏感的CEST代理,使用RBCs中的偏磁转移水.
与现有的CEST代理相比,该系统提供了更高的灵敏度.
拟议的带有胺的红细胞表现有前途,作为MRI中瘤血液体积的记者.

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