相关实验视频
Updated: May 4, 2026

10:36
Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
21.1K
针对自闭症和其他神经发育障碍的有效益生菌
Jack A Gilbert1, Rosa Krajmalnik-Brown2, Dorota L Porazinska3
1Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA; Department of Ecology and Evolution, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637, USA.
Cell
|December 24, 2013
概括
肠道微生物影响小鼠自闭症谱系障碍 (ASD) 症状. 一种特定的益生菌, Bacteroides fragilis,缓解了类似ASD的行为,这表明神经发育障碍的潜在治疗策略.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物组在宿主健康和疾病中起着至关重要的作用.
- 肠道微生物组成的改变与各种神经发育障碍有关.
- 了解肠-大脑轴对于新的治疗方法至关重要.
研究的目的:
- 在小鼠模型中调查肠道微生物与自闭症谱系障碍 (ASD) 症状之间的因果关系.
- 为了确定与ASD相关的特定微生物转移.
- 评估益生菌对ASD的治疗潜力.
主要方法:
- 利用一只表现出类似自闭症行为的小鼠模型.
- 分析了肠道微生物组成和相关代谢产物.
- 用一种特定的益生菌Bacteroides fragilis来评估症状变化.
主要成果:
- 在小鼠模型中,ASD症状是由肠道微生物组成和结构的变化引发的.
- 特定的微生物代谢物与观察到的ASD表型有关.
- 用Bacteroides fragilis治疗导致了类似ASD症状的缓解.
结论:
- 肠道微生物失调是导致ASD病变的一个因素.
- 细菌菌体 (Bacteroides fragilis) 显示出缓解自闭症症状的治疗潜力.
- 益生菌代表了开发神经发育障碍的新疗法的一个有希望的途径.
相关概念视频
Gut-Brain Axis
222
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
222
Autism Spectrum Disorder
2.0K
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
2.0K
Probiotics
296
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
296
Drugs for Treatment of Diarrhea-Predominant IBS
1.0K
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
1.0K
Development of Human Microbiota
61
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
61
Microorganisms in Medicine and Therapeutics
1.3K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.3K

