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Updated: May 3, 2026

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通过2-OG-依赖的二氧化原酶检测DNA.

Chi-Lin Tsai1, John A Tainer2

  • 1Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Cell
|December 24, 2013
PubMed
概括

与DNA结合的TET2的晶体结构揭示了它如何识别5甲基 (5mC) DNA基质. 这一发现揭示了5mC氧化机制,这对于表观遗传学,干细胞和癌症至关重要.

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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