一个双向电路开关将男性和女性大脑中的激素信号重定向
Johannes Kohl1, Aaron D Ostrovsky1, Shahar Frechter1
1Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Cell
|December 24, 2013
概括
无果基因重新连接Drosophila的大脑电路,在雄性和雌性中产生双形激素反应. 这种特定于性别的线缆通过控制嗅觉神经元连接来实现不同的行为.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 动物行为 动物行为
背景情况:
- 草的性激素cVA会在雄性和雌性中引发不同的行为反应.
- 男性和女性的早期嗅觉处理是相似的,这表明性别特定的布线发生在大脑的更深处.
研究的目的:
- 为了研究负责对Drosophila中性激素的二态反应的神经回路.
- 阐明无果基因在特定性别神经线路和费洛蒙处理中的作用.
主要方法:
- 在体内利用全细胞电生理学记录来自第三阶层嗅觉神经元.
- 研究了无果转录因子在调节神经元形态和连接性的作用.
- 进行了第三阶神经元的选择性男性化,以评估功能重新连接.
主要成果:
- 确定了两种不同的第三阶嗅觉神经元集群,具有二态激素反应:一种是男性特异的,一种是女性特异的.
- 证明无果基因控制树突定位,连接男性响应和断开女性响应神经元集群从费洛蒙输入.
- 表明无果的细胞自主作用可以功能性地重新连接神经元电路并改变激素反应.
结论:
- 由无果基因调节的第三阶嗅觉神经元中的性别特异性布线,是Drosophila.的性激素对二态反应的基础.
- 无果基因充当双向开关,通过电路重新连接,使雄性和雌性具有不同的行为输出.
- 这项研究揭示了一种简单的电路逻辑,通过细胞自主基因作用产生性别特异性行为.
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