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合成酸化p38α重复了蛋白激酶活性

K Phin Chooi1, Sébastien R G Galan, Ritu Raj

  • 1Chemistry Research Laboratory, Department of Chemistry, University of Oxford , Mansfield Road, Oxford OX1 3TA, U.K.

Journal of the American Chemical Society
|January 8, 2014
PubMed
概括

研究人员通过模仿180.位点的酸化来化学激活蛋白激酶p38α. 这种激活足以触发MAPK通路,并揭示了对激酶抑制机制的洞察力.

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