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RAFT水性分散聚合产生基于聚乙烯糖醇的双块共聚合物纳米物体,具有可预测的单相形态

Nicholas J Warren¹, Oleksandr O Mykhaylyk, Daniel Mahmood

¹Department of Chemistry, University of Sheffield , Brook Hill, Sheffield S3 7HF, United Kingdom.

Journal of the American Chemical Society

|January 10, 2014

概括

本研究详细介绍了一种使用可逆添加碎片链转移 (RAFT) 聚合制造生物相容聚合物纳米颗粒的新方法. 该过程允许精确控制纳米粒子形状,包括球体,虫和囊泡,用于生物医学应用.

科学领域:

聚合物化学聚合物化学
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

聚乙烯甘醇 (PEG) 宏分子链转移剂 (宏CTA) 对于受控的聚合物合成至关重要.
可逆添加碎片链转移 (RAFT) 聚合使得精确定义的聚合物的合成成为可能.
水性分散聚合是一种绿色化学方法,用于纳米粒子合成.

研究的目的:

为了合成一种用于RAFT聚合的新型PEGylated dithiobenzoate宏CTA.
通过使用RAFT研究基于聚-2-基甲基酸盐 (PHPMA) 的二区块共聚合物的合成.
控制PEG-PHPMA双块共聚物的自我组装成各种纳米结构.

主要方法:

PEG113-dithiobenzoate macro-CTA的三步合成. 这是一个非常简单的方法.
使用合成的宏-CTA.使用HPMA的RAFT水性分散聚合.
使用NMR,GPC,DLS,TEM和SAXS进行表征.

主要成果:

高产率 (>95%) 和功能性 (>97%) 的PEG113-dithiobenzoate宏CTA.
控制HPMA的聚合,具有较低的多分散性 (M{\displaystyle M}w/M{\displaystyle M}n) <1.25) 和良好的阻塞效率.
可调节自组装成球体,虫和囊泡,最多含有17.5%的固体.
在20%的固体质量下观察有大约三种膜的藻状囊泡.
构建一个PEG113-PHPMA(x) 阶段图,用于可复制形态控制.

结论:

开发了一个强大的RAFT PISA配方,用于合成PEGylated双块共聚合物纳米物体.
该方法可以精确控制纳米粒子形态 (球体,虫,囊泡,状囊泡).
开发的配方适用于生物医学应用的生物相容,热响应纳米结构的合理和高效合成.

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