用于成像应用的Ln(III) 卷轴卷轴的新设计
Matthew R Berwick1, David J Lewis, Andrew W Jones
1School of Chemistry and ‡School of Biosciences, University of Birmingham , Edgbaston, B15 2TT, United Kingdom.
Journal of the American Chemical Society
|January 11, 2014
概括
研究人员设计了一种新型的 (MB1),它与胺离子自组合成一个三链绕的线圈. 这个结构显示了发光和磁共振对比特性,表明了新的成像剂的潜力.
科学领域:
- 生物分子工程是生物分子工程.
- 协调化学 协调化学
- 材料科学是一种材料科学.
背景情况:
- 设计用于自我组装的新序列对于创建先进的功能材料至关重要.
- 兰化离子具有独特的发光和磁性,在生物医学应用中非常有价值.
研究的目的:
- 设计和描述一种新序列 (MB1),能够与三价兰坦化离子进行自我组装.
- 为了研究由此产生的金属线圈复合物的结构和功能性质,Ln(III)(MB1)3.3.
主要方法:
- 体设计包含在疏水核中的化物结合部位.
- (MB1) 与三价兰坦化离子的自组合.
- 使用光谱和磁共振技术对由此产生的三链金属绕线圈进行表征.
主要成果:
- 成功设计了MB1序列,使其能够自组装成一个三链金属绕线圈 (Ln(III) ((MB1) 3).
- 卷卷的线圈呈现光发,这表明水对坦化离子的获取受到限制.
- 加多线圈显示出有希望的磁共振对比能力.
结论:
- 实际上,MB1与兰化物离子进行自组,形成稳定的金属环绕线圈结构.
- 开发的 terbium 和 gadolinium 卷轴线圈显示出在基于发光的探测和磁共振成像中的应用潜力.
相关概念视频
Magnetic Resonance Imaging
7.6K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
7.6K
Imaging Studies IV: Magnetic Resonance Imaging
427
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
427
Two-Dimensional (2D) NMR: Overview
1.6K
The 1D NMR spectrum of large and complex molecules like natural products has complicated splitting patterns and overlapping signals, which can be easily interpreted using 2-dimensional (2D) NMR. Unlike 1D NMR, 2D NMR has two frequency axes that provide the coupling information between the nucleus A and nucleus B in a molecule. The process from which 2D spectra are obtained has four steps.
The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse....
The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse....
1.6K
Imaging Studies III: Computed Tomography
893
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
893


