在研究设计,进行和分析方面增加价值并减少浪费
John P A Ioannidis1, Sander Greenland2, Mark A Hlatky3
1Stanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, Stanford, CA, USA; Division of Epidemiology, School of Medicine, Stanford University, Stanford, CA, USA; Department of Statistics, School of Humanities and Sciences, Stanford University, Stanford, CA, USA; Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA, USA.
研究设计,实施和分析方面的缺陷使生物医学和公共卫生研究受到损害. 实施诸如改进的协议和劳动力培训等解决方案可以提高研究质量和可靠性.
科学领域:
- 生物医学研究生物医学研究
- 公共卫生研究 公共卫生研究
- 科学方法学科学方法学
背景情况:
- 研究设计,进行和分析的缺陷经常产生误导性的结果和浪费资源.
- 挑战包括区分小效应与偏见,文档不足,统计能力不足以及对正在进行的研究的考虑不足.
- 研究人员的问题,如缺乏经验丰富的统计学家和利益冲突,进一步阻碍了可靠的研究.
研究的目的:
- 确定生物医学和公共卫生研究中常见的,可纠正的弱点.
- 提出可行的解决方案,以提高研究成果的质量,可靠性和可重复性.
- 解决影响研究完整性和资源分配的系统性问题.
主要方法:
- 在研究设计,执行和统计分析中分析常见的陷.
- 确定影响研究质量的与劳动力相关的挑战和激励结构.
- 制定建议,以加强研究协议,文档和劳动力培训.
主要成果:
- 确定了研究协议,文档,统计实践和劳动力专业知识中的重要问题.
- 强调了利益冲突和错误的奖励系统对研究质量的负面影响.
- 提出了一种多方面的方法来解决这些弱点.
结论:
- 提高研究质量需要解决设计,行为,分析和劳动力发展方面的弱点.
- 增强的协议,更好的文档和优化的培训对于可靠的科学证据至关重要.
- 审查科学奖励系统以优先考虑质量和可靠性而不是数量和新性是必不可少的.
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