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Daniela Ponader1, Pauline Maffre, Jonas Aretz

  • 1Max Planck Institute of Colloids and Interfaces, Research Campus Golm , Am Mühlenberg 1, 14424 Potsdam, Germany.

概括

设计具有多种糖类型 (异种多重性) 的人工糖联体显著增强了与莱克受体的结合亲和力,为分子相互作用和药物开发提供了新的见解.

相关概念视频

Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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