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限制周期性酸抗生素的构造动态,可以改善它们的抗菌活性

Daniel W Carney1, Karl R Schmitz, Jonathan V Truong

  • 1Department of Chemistry, Brown University , 324 Brook Street, Providence, Rhode Island 02912, United States.

Journal of the American Chemical Society
|January 16, 2014
PubMed
概括

新的循环乙烯基 (ADEP) 抗生素显示出增强的抗菌活性. 通过药物化学稳定它们的构造,改善了ClpP化酶的结合和激活,导致明显更强的细菌杀死.

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