Gd3N@C84(OH) x:一种新的蛋形金属烯磁共振成像对比剂
Jianyuan Zhang1, Youqing Ye, Ying Chen
1Virginia Tech Carilion Research Institute , Roanoke, VA, 24016, United States.
Journal of the American Chemical Society
|January 18, 2014
概括
使用金属烯的新型基于加多的MRI对比剂显示性能增强. 一种新的Gd3N@C84衍生物显示出更高的放松性,使其成为先进医学成像的有希望的候选人.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 医疗成像医学成像
背景情况:
- 含加多的金属烯是有前途的MRI对比剂,由于高放松性和安全封装Gd(3+).
- 三金属化物模板内体金属 (TNT EMF) 提供增强的稳定性,产量和三重Gd3+) 封装.
研究的目的:
- 为了制备和功能化一个低对称的内分体金属烯 (EMF),Gd3N@C(s) -C84.
- 为了评估Gd3N@C84与Gd3N@C80.0相比的MRI对比剂特性.
主要方法:
- Gd3N@C(s) -C84.4 的合成和功能化
- 在各种磁场 (0.47 T, 1.4 T, 9.4 T) 上进行质子磁共振 (1H MR) 放松度测量.
- 用X射线光电子光谱 (XPS) 和动态光散射 (DLS) 来进行表征.
主要成果:
- 在所有测试的磁场中,Gd3N@C84衍生物的1H MR放松度高于Gd3N@C80.
- 与Gd3N@C80.0相比,Gd3N@C84的基含量和聚合物大小增加.
- 在Gd3N@C84中,较高的放松性可能归因于基含量和聚合物大小的增加.
结论:
- 与Gd3N@C80.s相比,低对称的Gd3N@C(s) -C84是一种优越的MRI对比剂.
- 功能化策略导致酸含量增加和聚合物大小增加,提高MRI放松性.
- Gd3N@C84衍生物代表了MRI对比剂开发的重大进展.
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