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Comparative RNA Structure Analysis of Nascent and Mature Transcripts in Saccharomyces cerevisiae
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低效的SRP与新生链的相互作用触发了mRNA质量控制途径

Andrey L Karamyshev1, Anna E Patrick1, Zemfira N Karamysheva1

  • 1Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

Cell
|January 21, 2014
PubMed
概括

细胞系统可以防止有毒蛋白质的积累. 分泌蛋白质的缺陷会触发Argonaute2 (Ago2) 降解它们的mRNA,通过一种新的翻译质量控制机制防止异常蛋白质的产生.

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