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Updated: May 3, 2026

Isolating Potentiated Hsp104 Variants Using Yeast Proteinopathy Models
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Published on: November 11, 2014

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增强的Hsp104变体对抗各种蛋白质毒性错折事件

Meredith E Jackrel1, Morgan E DeSantis2, Bryan A Martinez3

  • 1Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Cell
|January 21, 2014
PubMed
概括

科学家们重新编程了酵母Hsp104以创建强大的变体,可以溶解涉及ALS和帕金森等神经退行性疾病的有毒蛋白质聚合物. 这些增强的分聚酶可以恢复蛋白质静止,并减轻神经退行.

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