塔基基宁表达神经元控制雄性特异性Drosophila的侵略性兴奋
Kenta Asahina1, Kiichi Watanabe1, Brian J Duistermars1
1Howard Hughes Medical Institute, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA; Division of Biology, 156-29, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA.
Cell
|January 21, 2014
概括
一个表达塔基基宁 (Tk) 的特定神经元驱动果的雄性攻击. 这种神经系统控制着攻击性行为,提供了对跨物种侵略性保护机制的见解.
科学领域:
- 神经科学是一个神经科学.
- 行为遗传学 行为遗传学
- 进化生物学 进化生物学
背景情况:
- 攻击性性二态性是常见的,但它的神经基础在很大程度上仍然未知.
- 了解性别行为差异的遗传和神经基础至关重要.
研究的目的:
- 为了确定负责Drosophila melanogaster中更高的男性侵略性的特定神经元和基因.
- 阐明神经在调节性特异性侵略性行为中的作用.
主要方法:
- 利用基因操纵来激活和沉默果中的特定神经元.
- 研究了神经分泌物塔基基宁 (Tk) 和它的受体 (Takr86C) 对攻击性的影响.
- 检查了感官和上下文线索对侵略行为的影响.
主要成果:
- 在男性中确定了一组表达塔基基宁 (Tk) 神经元的性二态集群,该集群控制着男性之间的侵略.
- 激活Tk神经元增加了侵略性;沉默降低了它,而不影响求爱.
- Tk和Takr86C基因突变调节了侵略性,而Tk过度表达则强化了它.
结论:
- 神经分泌物塔基基宁 (Tk) 和它的受体在果的雄性特异性攻击中发挥着关键作用.
- 这种Tk系统似乎调节了积极的兴奋或动机,取代了感官输入.
- 这些发现表明,塔基基宁信号在包括哺乳动物在内的多种物种的侵略中起着保留的作用.
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