一个同体的金属有机框架作为一个有效的不对称的催化剂,用于水素合成
1School of Chemistry and Chemical Technology and State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University , Shanghai 200240, China.
Journal of the American Chemical Society
|January 23, 2014
概括
一种新型的同体性金属有机框架 (MOF) 作为不对称的化反应的有效异质催化剂. 这种可回收的MOF催化剂与同质催化剂相比,表现出更高的活性和酶选择性.
科学领域:
- 材料科学 材料科学 材料科学
- 有机化学 有机化学
- 催化剂是一种催化剂.
背景情况:
- 同人体金属有机框架 (MOFs) 是对不对称催化有希望的.
- 开发高效和可回收的异质催化剂对于可持续化学至关重要.
研究的目的:
- 为了构建一个同质基的MOF使用一个enantiopure 2,2'-dihydroxy-1,1'-biphenyl连接体.
- 评价MOF作为异质催化剂的性能,用于化物不对称的化.
主要方法:
- 合成一个同体基的MOF.
- 通过将质子换成 (I) 离子来修改MOF.
- 使用修改的MOF,对化物进行催化不对称的化.
主要成果:
- I交换的MOF证明了作为异质催化剂的高效率和可回收性.
- 在不对称的化中达到超过99% ee的反选择性.
- 与同质对应物相比,表现出增强的催化活性和酶选择性,特别是在低的催化剂/基质比率下.
- 成功合成了98% ee的 (S) -bufuralol,展示了合成效用.
结论:
- MOF的刚性框架稳定了活性催化物种,从而提高了性能.
- 这种同体的MOF代表了异质不对称催化学的重大进步.
- 催化剂的可循环利用性和高反选择性为合成奇拉化合物提供了一种可持续的方法.
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