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Updated: Jul 10, 2026

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内皮细胞瘤在携带多瘤病毒的转基因小鼠中发生,中T基因瘤基因病毒

V L Bautch1, S Toda, J A Hassell

  • 1Cold Spring Harbor Laboratory, New York 11724.

Cell
|November 20, 1987
PubMed
概括

转基因小鼠表达多瘤中间T抗原 (MT) 发展致命的内皮瘤,揭示了其在破坏血管生长控制中的作用. 这些小鼠为研究血管生成提供了一个新的模型.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...