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由内皮细胞衍生的血管蛋白-2 控制肝脏再生作为一个空间时空的静态

Junhao Hu¹, Kshitij Srivastava, Matthias Wieland

¹Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ), DKFZ-Center for Molecular Biology Alliance, 69120 Heidelberg, Germany.

Science (New York, N.Y.)

|January 25, 2014

概括

肝脏的再生依赖于协调的细胞生长. 来自肝脏侧鼻内皮细胞 (LSECs) 的 ангиопоетин-2 (Ang2) 在肝脏修复过程中动态控制肝细胞和LSEC增殖.

科学领域:

肝病学肝病学是一种肝病学.
血管生物学血管生物学
再生医学是一种再生医学.

背景情况:

肝脏的再生需要肝细胞和肝脏侧侧内皮细胞 (LSECs) 之间的精确协调.
在肝脏修复过程中控制这种交叉语音的分子机制尚未完全理解.
了解LSEC介导的信号传递对于增强肝脏再生至关重要.

研究的目的:

在肝脏再生过程中调查LSEC中 ангиопоэтин-2 (Ang2) 的动态调节和功能.
阐明Ang2如何影响肝细胞和LSEC增殖.
定义LSECs作为肝脏再生的管弦乐队的作用.

主要方法:

在小鼠模型中进行部分肝切除术.
在LSEC中对 ангиопоэтин-2 (Ang2) 表达的分析.
评估转化生长因子-β1和血管内皮生长因子受体2水平.
肝细胞和LSEC增殖率的评估.

主要成果:

在LSEC中,angiopoietin-2 (Ang2) 表达在部分肝切除术后是动态调节的.
在LSEC中早期的Ang2下调会降低TGF-β1,促进肝细胞的增殖.
后来Ang2表达的恢复通过调节LSEC中的VEGFR2来促进再生性血管生成.

结论:

LSECs 作为一个动态的静电控制肝脏再生.
来自LSECs的angiopoietin-2 (Ang2) 在空间和时间上协调肝细胞和LSEC的增殖.
这项研究揭示了在肝脏修复过程中血管和自身信号传递的新机制.

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