灵长类淋巴细胞的HIV感染和CD4受体的保存

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Updated: Jul 26, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
14:23

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

M O McClure1, Q J Sattentau, P C Beverley

  • 1Chester Beatty Laboratories, Institute of Cancer Research, London, UK.

Nature
|December 3, 1987
PubMed
概括

人类免疫缺陷病毒 (HIV) 感染表达CD4抗原的灵长类细胞. 这一发现允许对抗艾滋病 (获得性免疫缺陷综合征) 的抗病毒药物和疫苗进行评估.

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Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...