长期强化和NMDA受体在老鼠视觉皮层中的长期强化和NMDA受体
1Max Planck Institute for Brain Research, Department of Neurophysiology, Frankfurt, FRG.
Nature
|December 17, 1987
概括
长期强化 (LTP) 是一种突触可塑性的形式,可以在视觉皮层中诱导. 激活NMDA受体和减少GABAergic抑制对于诱导新皮质中的LTP至关重要.
科学领域:
- 神经科学是一个神经科学.
- 突触性可塑性 突触性可塑性
背景情况:
- 长期增强 (LTP) 在海马体中已经很成熟,但在新皮质中仍然难以捉摸.
- 新皮质在学习中的作用表明了像LTP这样的突触可塑性机制的潜力.
研究的目的:
- 为了研究LTP在老鼠视觉皮层中的诱导.
- 确定新皮层中LTP所需的条件.
主要方法:
- 成年老鼠视觉皮层切片中的细胞内记录技术.
- 光学辐射的高频刺激.
- 使用NMDA受体对抗剂和GABAA受体对抗剂的药理学操纵.
主要成果:
- 在视觉皮层通过高频刺激成功诱导LTP.
- 激活NMDA受体是LTP诱导的先决条件.
- 在大多数皮层神经元中,减少GABAergic抑制,使用bicuculline,对于NMDA受体激活和随后的LTP诱导是必要的.
结论:
- 可以在老鼠视觉皮层中诱导LTP.
- 激活NMDA受体对于新皮层LTP至关重要.
- 抑制过程显著影响新皮质中NMDA受体激活和LTP诱导的值.
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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
01:25Long-term Potentiation
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