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相关概念视频

Membrane Domains01:18

Membrane Domains

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The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the...
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Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

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Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
8.0K
Distribution of Cytoplasmic Content02:33

Distribution of Cytoplasmic Content

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Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of...
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What are Lipids?01:38

What are Lipids?

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What are Lipids?01:31

What are Lipids?

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Lipids function as structural components of cellular membranes, in addition to acting as energy reservoirs and signaling molecules. They are thus crucial to all living organisms.  The three biologically important classes of lipids are triglycerides, phospholipids, and steroids.
Non-Polar and Hydrophobic Characteristics of Lipids
Lipids are a structurally and functionally diverse group of hydrocarbons—compounds consisting of carbon and hydrogen atoms. The carbon-carbon and...
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Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

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Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
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Lipid Exchange Assay in Living Cells
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分裂细胞调节它们的脂质组成和局部化.

G Ekin Atilla-Gokcumen1, Eleonora Muro2, Josep Relat-Goberna3

  • 1Department of Biological Chemistry and Molecular Pharmacology and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Cell
|January 28, 2014
PubMed
概括
此摘要是机器生成的。

细胞分裂涉及显著的膜变化. 这项研究表明,细胞在分裂期间积极调节脂质组成和局部化,影响细胞力学和中体形成.

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科学领域:

  • 细胞生物学 细胞生物学
  • 生物化学 生物化学
  • 生物物理学的生物物理.

背景情况:

  • 细胞分裂需要广泛的膜重组.
  • 脂质在细胞分裂中的特定作用在很大程度上是未知的.
  • 了解脂质动态对于理解细胞周期进展至关重要.

研究的目的:

  • 为了研究细胞周期期间脂质组的变化.
  • 为了确定参与细胞分裂的特定脂质和酶.
  • 探索分裂细胞及其脂质的机械特性.

主要方法:

  • 液体染色学-质谱学 (LC-MS) 用于脂质分析.
  • 原子力显微镜 (AFM) 用于评估机械性能.
  • RNA干扰 (RNAi) 用于识别必需的脂质生物合成酶.

主要成果:

  • 在分裂的细胞中积累了11种特定的脂质.
  • 与非分裂细胞相比,分裂细胞具有不同的机械特性.
  • 脂质局部化到中间体在细胞分裂期间被积极调节.

结论:

  • 细胞在分裂过程中动态调节脂质组成和局部化.
  • 脂质在细胞分裂中起到信号和结构作用.
  • 这项研究强调了脂质在基本生物过程中的不可或缺的作用.