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RNA-Associated Chromatin DNA-DNA Interaction Method
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含有SRA和SET域的蛋白质将RNA聚合酶V占用与DNA甲基化联系起来

Lianna M Johnson1, Jiamu Du2, Christopher J Hale1

  • 1Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA 90095, USA.

Nature
|January 28, 2014
PubMed
概括

SUVH2和SUVH9蛋白质将RNA聚合酶V招募到DNA甲基化位点,从而使植物中的向表观遗传基因沉默成为可能. 这种机制依赖于它们的SRA域结合甲基化DNA,而不是催化活性.

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