取决于细胞分裂的时间机制是由植物干细胞中的Polycomb驱逐引起的
Bo Sun1, Liang-Sheng Looi, Siyi Guo
1Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604, Republic of Singapore.
Science (New York, N.Y.)
|February 1, 2014
概括
植物花干细胞使用一个依赖分裂的表观遗传定时器来控制发育. 花的蛋白质AGAMOUS (AG) 通过去除Polycomb蛋白来触发这个定时器,从而使KNUCKLES (KNU) 基因表达.
科学领域:
- 植物发育生物学植物发育生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 花发育的分子机制
背景情况:
- 花的干细胞在终端分化之前具有有限的增殖能力.
- 花的干细胞分裂和分化的精确时间对于生殖发育至关重要.
- 控制植物干细胞循环退出的监管机制尚未完全理解.
研究的目的:
- 阐明控制花干细胞分化的时间的表观遗传机制.
- 确定参与花发育时间控制的关键调节者.
- 了解植物在细胞水平上如何测量发育时间.
主要方法:
- 在Arabidopsis花发育中的基因表达模式的分析.
- 染色体免疫沉以确定蛋白质-DNA相互作用.
- 研究Polycomb组蛋白和花同源蛋白的作用.
- 研究AGAMOUS (AG) 约束对KNU基因调节的影响.
主要成果:
- 花的同源蛋白 AGAMOUS (AG) 诱导指抑制剂 KNUCKLES (KNU) 延迟约2天.
- AG绑定站点位于KNU上游地区的Polycomb响应元件附近.
- 结合AG导致Polycomb组蛋白从KNU位点被驱逐出去.
- 这种Polycomb驱逐触发了KNU的细胞分裂依赖诱导.
结论:
- 花的干细胞利用一个取决于分裂的表观遗传定时器来测量发育时间.
- 由AGAMOUS调解的多组蛋白质驱逐,是这个定时器的关键触发器.
- 这种机制确保了花干细胞的协调生长和及时分化.
相关概念视频
01:27Molecular Factors Affecting Cell Division
3.9K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
3.9K
02:13Determining the Plane of Cell Division
2.7K
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
2.7K
02:13Determining the Plane of Cell Division
1.4K
1.4K
01:30Animal and Plant Cell Structure
31.4K
Animal and plant cells not only differ in their structure, function, and mode of nutrition but also in how they reproduce, specialize, and organize into complex structures.
Cell Division
Though both plant and animal cells divide by mitosis (for non-gametic cells) and meiosis (for gametic cells), they differ in the specifics of this process. Unlike animal cells, plant cells lack centrosomes — an organelle responsible for organizing the spindle fibers and segregating the chromosomes during...
Cell Division
Though both plant and animal cells divide by mitosis (for non-gametic cells) and meiosis (for gametic cells), they differ in the specifics of this process. Unlike animal cells, plant cells lack centrosomes — an organelle responsible for organizing the spindle fibers and segregating the chromosomes during...
31.4K
01:28The Cell Cycle Control System
5.1K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
5.1K
02:11The Cell Cycle Control System
11.9K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
11.9K