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哨兵和助手巨细胞之间的交叉声允许中性粒细胞迁移到受感染的尿表皮质中

Marzena Schiwon¹, Christina Weisheit², Lars Franken¹

¹Institute of Experimental Immunology, University Clinic of Bonn, 53127 Bonn, Germany.

|February 4, 2014

概括

哨兵巨细胞和助手巨细胞协调对抗细菌感染的天生的免疫力. 助手巨细胞激活哨兵巨细胞来招募中性粒细胞,以便在上皮组织中有效清除细菌.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
细胞生物学细胞生物学

背景情况:

巨细胞和中性粒细胞是对细菌天生的免疫力中的关键细胞.
不同的细胞子集在细菌防御中的具体作用和合作尚不清楚.

研究的目的:

阐明不同细胞子集在细菌性尿路感染中的协调作用.
确定在上皮细胞细菌感染期间的细胞专业化和合作的基础机制.

主要方法:

使用了细菌性尿路感染的小鼠模型.
采用流细胞计和细胞因子/化学因子分析来识别和表征细胞子集.
研究了涉及巨细胞和中性粒细胞的细胞间通信通路.

主要成果:

鉴定了三种不同的细胞子集,它们在细菌性尿路感染中发挥着协调作用.
Ly6C(-) 巨细胞作为哨兵,吸引中性粒细胞和Ly6C(+) 巨细胞.
Ly6C(+) 辅助巨细胞产生TNF,诱导Ly6C(-) 巨细胞分泌CXCL2,从而激活中性粒细胞矩阵金属蛋白酶-9用于尿上皮细胞入侵.

结论:

哨兵和助手巨细胞在上皮组织中协调中性粒细胞的抗菌功能.
这种协调的免疫反应对于对抗细菌感染至关重要.
这些发现揭示了先天性免疫的新型调节机制,涉及辅助巨细胞和TNF,这对表皮细胞对细菌的防御至关重要.

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