通过额外桃体的七海马体电路控制压力诱导的持续焦虑
Todd E Anthony1, Nick Dee2, Amy Bernard2
1Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, M/C 156-29, Pasadena, CA 91125, USA.
Cell
|February 4, 2014
概括
侧隔膜 (LS) 通常可以抑制焦虑. 然而,这项研究发现,表达2型CRF受体 (Crfr2) 的特定LS神经元子集实际上可以增强焦虑行为和压力激素水平.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 内分泌学 在内分泌学.
背景情况:
- 扩展的杏仁体是恐惧和焦虑研究的主要焦点.
- 七海马轴,包括侧隔膜 (LS),也显著影响焦虑.
- 在LS中特定的神经元群体的作用,特别是表达2型CRF受体 (Crfr2) 的神经元群体的作用,仍然不清楚.
研究的目的:
- 调查LS中Crfr2表达神经元的功能连接.
- 确定这些LS神经元在焦虑和压力反应中的作用.
- 在LS电路中识别细胞目标以调节焦虑.
主要方法:
- 利用光遗传学来选择性地激活或抑制LS中的Crfr2-阳性 (Crfr2(+)) 神经元.
- 研究了操纵Crfr2(+) LS神经元对动物模型中压力诱导的焦虑行为的影响.
- 测量循环皮质类固醇水平,以评估内分泌影响.
主要成果:
- 确定了Crfr2(+) 细胞作为连接到前垂体的GABAergic投射神经元.
- 发现LS Crfr2(+) 输出令人惊地增强了压力诱导的焦虑行为.
- 证明激活Crfr2(+) 神经元促进,同时抑制它们抑制,持续的焦虑.
结论:
- 一个特定的LS投射神经元子集,由Crfr2表达标记,促进而不是抑制焦虑.
- 这些发现揭示了一个新的电路机制,LS输出可以加剧焦虑.
- 这项研究为了解和潜在地针对焦虑障碍中的LS电路提供了一个细胞入口点.
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