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熟练的接触依赖于一个V2a自身脊柱内部复制电路
Eiman Azim1, Juan Jiang2, Bror Alstermark2
1Howard Hughes Medical Institute, Kavli Institute for Brain Science, Mortimer B. Zuckerman Mind Brain Behavior Institute, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
Nature
|February 4, 2014
概括
宫自身脊髓神经元 (PNs) 提供了运动指令的内部副本,这对于精确的前肢伸展至关重要. 删除或激活这些V2a PNs会破坏目标定向的达到,突出显示它们在运动控制中的作用.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 脊髓生理学 脊髓生理学
背景情况:
- 熟练的前肢运动精度被认为取决于反校正的运动命令的内部副本.
- 这些内部复制回路的功能作用,特别是在脊髓中,仍然不太清楚.
研究的目的:
- 为了研究椎自身脊髓神经元 (PNs) 作为目标导向前肢伸展中的内部复制通路的作用.
- 为了确定V2a内部神经元,PNs的一个亚群,是否参与了这个运动控制机制.
主要方法:
- 在小鼠的宫V2a内部神经元的向性切除.
- 对PN内部复制通路的光遗传激活.
- 在完成任务时分析前肢运动动力学.
主要成果:
- 切除V2aPNS特异性损害了伸手行为,而其他前肢运动仍然完好无损.
- 通过小脑反循环调节运动神经元活动,PN内部复制通路的光遗传激活扰乱了达到动力学.
- 这些发现表明,V2a PNs是快速更新电机输出的内部复制路径的组成部分.
结论:
- 宫V2a PNs作为一个关键的内部复制通道,用于精确的,目标导向的前肢伸展.
- 这一途径通过影响小脑反循环和运动神经元活动,快速更新运动输出.
- 这项研究涉及V2a PNs在运动执行的实时调制.
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