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特定序列的DNA结合分子的设计,用于DNA甲基转移酶抑制

JeenJoo S Kang1, Jordan L Meier, Peter B Dervan

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, California 91125, United States.

Journal of the American Chemical Society
|February 8, 2014
PubMed
概括

研究人员开发了新的小分子,以准DNA甲基化控制的CPG位点. 一个分子,发针3,有效地抑制了DNA甲基转移酶活性,为新的表观遗传疗法提供了基础.

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