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异常的化物细胞内通道4表达有助于肺动脉高血压中的内皮功能障碍

Beata Wojciak-Stothard1, Vahitha B Abdul-Salam, Ka Hou Lao

  • 1Centre for Pharmacology and Therapeutics, Department of Medicine, Imperial College London, London, UK (B.W.-S., V.B.A.-S., K.H.L., H.T., R.J.E., C.J.R., J.W., L.Z., M.R.W.); Cardiovascular Pulmonary Research Group, University of Colorado Denver Health Sciences Center, Aurora (D.C.I., C.L., Z.L., K.R.S.); Division of Nephrology, Department of Internal Medicine, St. Louis University, St. Louis MO (J.C.E.); Laboratory of Cancer Biology & Genetics, Centre for Cancer Research, Bethesda, MD (S.H.Y.); and National Pulmonary Hypertension Service and National Heart & Lung Institute, Imperial College Healthcare NHS Trust, London, UK (L.S.H., J.S.R.G.).

Circulation
|February 8, 2014
PubMed
概括

化物细胞内通道4 (CLIC4) 在肺高血压中升高,导致内皮功能障碍. 在肺动脉内皮细胞中抑制CLIC4改善了屏障功能并减少了异常细胞生长.

关键词:
诱导血管生成的诱导剂它们的内皮质 (endothelium).高血压,肺部高血压,肺部高血压.缺氧诱导因子1 1核因子-卡帕BBB

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