一个致力于先导先天性淋巴细胞的前体
Michael G Constantinides1, Benjamin D McDonald1, Philip A Verhoef1
1Committee on Immunology, Department of Pathology, The Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA.
Nature
|February 11, 2014
概括
研究人员发现了一种新的前体细胞,即先天性淋巴细胞前体 (ILCP),它是由转录因子PLZF定义的. 这一发现澄清了先天性淋巴细胞 (ILC),自然杀手细胞 (NK) 和淋巴组织诱导体 (LTis) 之间的发育关系.
科学领域:
- 免疫学 免疫学 免疫学
- 发育生物学 发展生物学
- 细胞生物学 细胞生物学
背景情况:
- 天生的淋巴细胞 (ILC) 对免疫和组织修复至关重要,但它们的发育起源和与其他天生的淋巴细胞的关系仍然不清楚.
- 目前将ILC分为第一,第二和第三组的分类是基于细胞因子概况,而不是发育途径.
- ILCs,自然杀手 (NK) 细胞和淋巴组织诱导体 (LTis) 之间的相似性表明它们具有共同的发育起源.
研究的目的:
- 识别和描述先天性淋巴细胞的新型前体.
- 阐明ILCs,NK细胞和LTis的发育途径和血统关系.
- 确定转录因子PLZF在先天性淋巴细胞分化中的作用.
主要方法:
- 在小鼠胎儿肝脏和成年骨髓中进行血统追踪和转移研究.
- 一种表达高水平PLZF的新型淋巴细胞前体种群的特征.
- 分析PLZF删除后的ILC子集发展.
主要成果:
- 在小鼠免疫器官中识别了一种新型前体群,PLZF (高) 细胞.
- PLZF (高) 细胞表现出多能潜力,从而产生了ILC1,ILC2和ILC3子集.
- 删除PLZF显著影响了ILC子集的发展,证实了PLZF的关键作用.
- 这些前体与经典的LTi和NK细胞不同,但包括NK1.1(+) DX5(-) "NK样"细胞的子集.
结论:
- 在ILC,NK和LTi细胞之间建立新的血统关系.
- 确定ILCs的常见前体,称为先天性淋巴细胞前体 (ILCP).
- 确认转录因子PLZF在先天性淋巴细胞分化中的广泛和决定性作用.
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