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原油损害了鱼类的心脏激发 - 收缩的合
Fabien Brette1, Ben Machado, Caroline Cros
1Department of Biology, Stanford University, Hopkins Marine Station, Pacific Grove, CA 93950, USA.
Science (New York, N.Y.)
|February 18, 2014
概括
来自深水地平线漏油的原油通过阻断电流和扰乱循环来破坏鱼类心脏功能,导致心律失常.
科学领域:
- 心血管毒理学心血管毒理学
- 环境毒理学环境毒理学
- 海洋生物学 海洋生物学
背景情况:
- 原油泄漏对海洋生态系统构成重大威胁.
- 深水地平线 (DWH) 灾难影响了墨西哥湾的繁殖地点.
- 鱼类中原油心脏毒性的机制在很大程度上是未知的.
研究的目的:
- 研究DWH原油对鱼类的心脏毒性影响.
- 阐明原油引起的心脏功能障碍的生理机制.
- 确定对细胞刺激性和心脏功能的影响.
主要方法:
- 使用了从青青蓝和黄金枪鱼中分离出来的心肌细胞.
- 电生理学记录评估了离子通道功能 (和电流).
- 检查了对作用电位持续时间和激发-收缩合的影响.
主要成果:
- DWH原油通过阻断延迟的整流器电流 (I(Kr)) 来延长作用潜力.
- 原油暴露导致电流 (I(Ca)) 降低,循环受损.
- 在暴露的心肌细胞中观察到刺激-收缩合的破坏.
结论:
- 原油通过改变细胞电活动来产生心脏毒性.
- 阻断I ((Kr) 和减少I ((Ca)) 导致心脏功能障碍.
- 研究结果表明,暴露在原油中的鱼类可能会出现危及生命的心律失常.
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