下肢表面血栓炎的治疗方法
Marcello Di Nisio1, Saskia Middeldorp2
1Department of Medical, Oral, and Biotechnological Sciences, Università "G. D'Annunzio" of Chieti-Pescara, Chieti, Italy2Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.
JAMA
|February 20, 2014
概括
在患有下肢表面性血栓炎的患者中,芬达帕努克斯有效地减少了症状性静脉血栓栓塞事件 (VTE) 和表面性静脉血栓扩张. 其他治疗方法,如低分子量肝素,也显示出预防延长和复发的希望.
科学领域:
- 血管医学 血管医学
- 血栓形成研究研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 下肢表面性血栓炎是一种常见的疾病.
- 识别能够最大限度地减少并发症的治疗方法,如静脉血栓栓塞事件 (VTE) 和延伸,至关重要.
研究的目的:
- 为了评估治疗下肢表面血栓炎的治疗方法.
- 为了确定与较低的VTE率,较大的出血和表面静脉血栓扩张的相关性.
主要方法:
- 随机对照试验的系统审查和元分析.
- 与安慰剂相比,各种抗凝血剂和抗炎药物的比较.
主要成果:
- 与安慰剂相比,芬达巴林克斯 (每天2.5毫克,持续45天) 显著减少了症状性静脉动脉,表面静脉血栓扩张和复发,而没有增加严重出血.
- 低分子量肝素和非类固醇抗炎药物与延长/复发的减少有关,但VTE数据不确定.
结论:
- 芬达帕鲁努克斯是一种有前途的治疗下肢表面血栓炎,在静脉瘤预防和局部扩展方面具有好处.
- 需要进一步的研究来澄清LMWH和NSAIDs在预防这种疾病中的VTE中的作用.
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