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在Atg16l1中的克罗恩病变体增强了其通过caspase3降解

Aditya Murthy1, Yun Li1, Ivan Peng1

  • 1Department of Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.

Nature
|February 21, 2014
PubMed
概括

一种常见的克罗恩病风险基因变异 (ATG16L1 T300A) 对-3裂变更敏感. 这导致自减少和病原体清除受损,有助于克罗恩病的发展.

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