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C11orf95-RELA融合驱动瘤原性NF-κB信号在尾瘤中的信号传递

Matthew Parker1, Kumarasamypet M Mohankumar2, Chandanamali Punchihewa3

  • 11] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] Department of Computational Biology and Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA [3].

Nature
|February 21, 2014
PubMed
概括

研究人员发现了一种新的基因融合,C11orf95-RELA,在大多数 supratentorial ependymomas. 这种融合激活核因子-κB (NF-κB) 信号,驱动瘤形成并提供潜在的治疗点.

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